In vitro rosetting, cytoadherence, and microagglutination properties of Plasmodium falciparum-infected erythrocytes from Gambian and Tanzanian patients
نویسندگان
چکیده
منابع مشابه
α-Thalassemia Impairs the Cytoadherence of Plasmodium falciparum-Infected Erythrocytes
BACKGROUND α-Thalassemia results from decreased production of α-globin chains that make up part of hemoglobin tetramers (Hb; α(2)β(2)) and affects up to 50% of individuals in some regions of sub-Saharan Africa. Heterozygous (-α/αα) and homozygous (-α/-α) genotypes are associated with reduced risk of severe Plasmodium falciparum malaria, but the mechanism of this protection remains obscure. We h...
متن کاملImpaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin.
Sickle trait, the heterozygous state of normal hemoglobin A (HbA) and sickle hemoglobin S (HbS), confers protection against malaria in Africa. AS children infected with Plasmodium falciparum are less likely than AA children to suffer the symptoms or severe manifestations of malaria, and they often carry lower parasite densities than AA children. The mechanisms by which sickle trait might confer...
متن کاملAlteration in cytoadherence and rosetting of Plasmodium falciparum-infected thalassemic red blood cells.
Hemoglobinopathies have a protective role in malaria that appears to be related to alterations in red blood cell (RBC) properties. Thalassemic RBCs infected with Plasmodium falciparum showed greatly reduced cytoadherence and rosetting properties as well as impaired growth and multiplication. A significant decrease in the levels of falciparum antigens associated with the membrane of infected bet...
متن کاملplasmodium falciparum: adhesion phenotype of infected erythrocytes using classical and mini-column cytoadherence techniques.
background: cytoadherence of plasmodium falciparum - infected erythrocytes to host cells is an im-portant trait for parasite survival and has a major role in pathology of malaria disease. infections with p. falciparum usually consist of several subpopulations of parasites with different adhesive prop-erties. this study aimed to compare relative sizes of various binding subpopulations of differe...
متن کاملInvolvement of CD36 on erythrocytes as a rosetting receptor for Plasmodium falciparum-infected erythrocytes.
Plasmodium falciparum-infected erythrocytes (parasitized red blood cells [PRBCs]) can adhere to uninfected erythrocytes (RBCs) to form rosettes, and adhere to the endothelial cell (EC) surface antigen CD36. These adherence phenomena have previously been considered quite different. We show that anti-CD36 monoclonal antibodies (MoAbs) reverse rosetting of PRBCs from both a culture-adapted line (M...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1990
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v76.9.1845.1845